Explain the biochemical basis of NSAID nephropathy?

Learning Goal: I’m working on a biology writing question and need guidance to help me learn.Using information gleaned from your readings on Eicosanoids, give a clear biochemical response to these questions (Your answers should not be more than 2 pages):a. A 65 year old retired construction worker is referred to the dialysis clinic following a recent diagnosis of chronic kidney disease due to a prolonged use of of the NSAID Ibuprofen. Explain the biochemical basis of NSAID nephropathy?b. What is the biochemical rationale for the use of low dose aspirin in patients with coronary artery disease? Why is Ibuprofen not a good substitute for aspirin in this case?NSTRUCTIONSYou must give detailed and well-explained answers to the assignment questions for each module. It is your responsibility to give clear, easy to understand and precise explanations in your answers – you must be very convincing with your answers! All assignment submissions should be consistent with the following; Length of assignment – Not more than 2 pageso The title and reference pages are excluded from the page count. No abstract is needed. Format of assignment – AMA  Number of citations – At least 3 Acceptable sources – Peer-reviewed Journal articles and textbooks
Requirements: 2 pages